Administering ketoconazole (25mg/Kg) for 14 days in male wistar rat provokes testicular damage accompanied by changes in testosterone levels and immune function

Numéro de la revue: 27
Auteurs: Kamilia Guedri, Hacène Frih, Aziez Chettoum, Asma Latreche, Leila Sahraoui, Nadia Boukhris & Abdelkrim Tahraoui.
Laboratoire de Neuroendocrinologie Appliquée, Département de biologie, Faculté des Sciences Université  Badji Mokhtar Annaba. BP12, Annaba 23000, Algerie

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The objective of this study is to explore the effects of subchronic treatment of male Wistar rats with a high dose of KTCZ on immune and gonadal changes (testes). KTCN (25mg/kg) was administered to male Wistar rats orally for 14 days.
Ketoconazole generated weight changes (increased relative weight of thymus, adrenals and brain and decreased weight of testes), testicular tissue damage and a decrease in testosterone serum accompanied by immunosuppression (decrease in lymphocytes and increase in neutrophilia levels).
These changes in body weight and tissue could have several origins which glucocorticoids play the role of conductor.

Keywords: Ketoconazole – Testosterone – Immunosuppression – Testicular damage.