1<\/sup>Laboratory of Animal Ecophysiology, Department of Biology, Faculty of Sciences,University Badji Mokhtar-Annaba, Annaba 23000, Algeria.<\/p>\n 2<\/sup>Laboratory of Environmental Sciences and Agroecology, Department of biology, Faculty of Life and Natural Sciences, University Chadli Bendjedid- El Tarf, El Tarf 36000, Algeria.<\/p>\n 3<\/sup>Department of Agronomy, Institute of Veterinary Sciences and Agronomic Sciences, University El Hadj Lakhdar-Batna-1, Batna 05000, Algeria.<\/p>\n T\u00e9l\u00e9charger l’article ABSTRACT<\/strong><\/p>\n Organic solvents exposure has been shown to affect the functional integrity of various organs. The current study was carried out to evaluate the renal dysfunction induced by toluene (Tol) toxicity, and the potential protective role of Punica granatum <\/em>fresh peel aqueous extract (FPAE) in male rats. The orally treated rats were divided as follows: Control (C), positive controls (corn oil: 1.25 mL\/kg BW; and FPAE: 400 mg\/kg BW), Tol1: 275 mg\/kg BW, Tol2: 550 mg\/kg BW and a mixture each of FPAE-Tol1 and FPAE-Tol2. After 6-week study period, urea, creatinine, and uric acid were estimated, as well as renal histology and oxidative stress markers. Results showed that Tol group has significant increase of serum urea and creatinine levels, with a significant elevation in renal malondialdehyde (MDA) levels, and a significant decrease of glutathione content and glutathione peroxidase activity.\u00a0 FPAE co-administration partially retrieved the changes in almost all studied parameters compared with the Tol group. Tol induced histopathological kidney damage, which was minimized as a result of P. granatum<\/em> treatment. In conclusion, this study provides evidence that FPAE attenuates renal oxidative injury induced by Tol, supporting the traditional claims of its beneficial effects, possibly due to its antioxidant potential.<\/p>\n Key words: <\/strong>Antioxidant, kidney, oxidative stress, Punica granatum,<\/em> toluene, rats.<\/p>\n","protected":false},"excerpt":{"rendered":" Num\u00e9ro de la revue: Volume 30 , Num\u00e9ro 1 Fatma Zohra Arkoub1,2*, Rahma Boukarine1,2, Leila Hamdi1, Labiba Kahalerras3, Kamel Khelili1, and Cherif Abdennour1 1Laboratory of Animal Ecophysiology, Department of Biology, Faculty of Sciences,University Badji Mokhtar-Annaba, Annaba 23000, Algeria. 2Laboratory of … Lire la suite ![\"p2\"](\"\/wp-content\/uploads\/2014\/04\/p2.jpg\")
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