{"id":857,"date":"2014-04-22T13:02:13","date_gmt":"2014-04-22T12:02:13","guid":{"rendered":"http:\/\/localhost\/direction\/?p=857"},"modified":"2014-05-21T13:53:43","modified_gmt":"2014-05-21T12:53:43","slug":"the-design-and-analysis-of-sequential-clinical-trials","status":"publish","type":"post","link":"https:\/\/synthese.univ-annaba.dz\/?p=857","title":{"rendered":"The design and analysis of sequential clinical trials"},"content":{"rendered":"<p style=\"text-align: justify;\" align=\"center\"><strong>Num\u00e9ro de la revue<\/strong>: 26<br \/>\n<strong>Auteurs<\/strong>: Hayet Merabet<br \/>\nLaboratoire de Math\u00e9matiques Appliqu\u00e9es et Mod\u00e9lisation, D\u00e9partement de Math\u00e9matiques, Universit\u00e9 Mentouri &#8211; Constantine Route de Ain-El Bey, 25000 Constantine, Alg\u00e9rie<\/p>\n<p style=\"text-align: right;\"><a href=\"\/wp-content\/uploads\/2014\/04\/Synthese26-4.pdf\"><strong>T\u00e9l\u00e9charger l&rsquo;article<img loading=\"lazy\" decoding=\"async\" class=\" wp-image-709 alignright\" style=\"margin-top: -10px; margin-bottom: -10px;\" alt=\"p2\" src=\"\/wp-content\/uploads\/2014\/04\/p2.jpg\" width=\"37\" height=\"35\" srcset=\"https:\/\/synthese.univ-annaba.dz\/wp-content\/uploads\/2014\/04\/p2.jpg 113w, https:\/\/synthese.univ-annaba.dz\/wp-content\/uploads\/2014\/04\/p2-24x24.jpg 24w, https:\/\/synthese.univ-annaba.dz\/wp-content\/uploads\/2014\/04\/p2-48x46.jpg 48w\" sizes=\"auto, (max-width: 37px) 100vw, 37px\" \/><\/strong><\/a><\/p>\n<p style=\"text-align: left;\"><strong>Abstract <\/strong><\/p>\n<p style=\"text-align: justify;\">This work is a generalization and systematization of the methodology for clinical trials in a Bayesian framework. We have used a purely Bayesian sequential aspect. This article provides a solution fully Bayesian that incorporates the prevision in a global issue. In an intermediate analysis, the predictive inference focuses on all the data, the data available and future data, in this manner, the evaluation of the prevision error is not overvalued as in an approach that does take into account the future observation. We applied the proposed procedures to the Gaussian model and it was possible to reach an explicit form of the various probabilities of errors that the practitioner can make. Thus we can make available to the user an implementable tool and fully Bayesian.<br \/>\nThe sequential aspect of the treatment adopted in this paper is a particularly innovative element compared to existing technology; it also helps to reduce multiphase studies more ambitious than the existing, which for the patient makes the analysis more ethical since it allows a stoppage of the experience shorter and less tardy.<\/p>\n<p style=\"text-align: justify;\"><strong>Key Words:<\/strong> Predictive methods-Bayesian analysis-Clinical Trials-p-Value.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Num\u00e9ro de la revue: 26 Auteurs: Hayet Merabet Laboratoire de Math\u00e9matiques Appliqu\u00e9es et Mod\u00e9lisation, D\u00e9partement de Math\u00e9matiques, Universit\u00e9 Mentouri &#8211; Constantine Route de Ain-El Bey, 25000 Constantine, Alg\u00e9rie T\u00e9l\u00e9charger l&rsquo;article Abstract This work is a generalization and systematization of the &hellip; <a href=\"https:\/\/synthese.univ-annaba.dz\/?p=857\">Lire la suite <span class=\"meta-nav\">&raquo;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[128,129,127,130],"class_list":["post-857","post","type-post","status-publish","format-standard","hentry","category-synthese-n-26","tag-bayesian-analysis","tag-clinical-trials-p","tag-predictive-methods","tag-value"],"_links":{"self":[{"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/posts\/857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=857"}],"version-history":[{"count":11,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/posts\/857\/revisions"}],"predecessor-version":[{"id":1885,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/posts\/857\/revisions\/1885"}],"wp:attachment":[{"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}