{"id":3882,"date":"2014-10-21T13:45:17","date_gmt":"2014-10-21T12:45:17","guid":{"rendered":"http:\/\/dpubma.univ-annaba.dz\/?p=3882"},"modified":"2014-10-21T13:48:01","modified_gmt":"2014-10-21T12:48:01","slug":"la-gestation-chez-le-rat-wistar-a-t-elle-un-effet-moderateur-sur-la-neurotoxicite-du-toluene","status":"publish","type":"post","link":"https:\/\/synthese.univ-annaba.dz\/?p=3882","title":{"rendered":"La gestation chez le rat wistar a-t-elle un effet mod\u00e9rateur sur la neurotoxicit\u00e9 du tolu\u00e8ne ?"},"content":{"rendered":"
Num\u00e9ro de la revue<\/strong>: 25
\nAuteurs<\/strong>: Asma Latreche, Hac\u00e8ne Frih, Bachir Ali Rachedi, Redha Djenidi, Kamilia Guedri, Hakima Taya, Leila Sahraoui & Abdelkrim Tahraoui<\/div>\n
Laboratoire de Neuroendocrinologie Appliqu\u00e9e, D\u00e9partement de Biologie,<\/div>\n

Facult\u00e9 des sciences, Universit\u00e9 Badji Mokhtar Annaba, BP 12 23000, Annaba, Alg\u00e9rie.<\/p>\n

 <\/p>\n

T\u00e9l\u00e9charger l’article\"p2\"<\/strong><\/a><\/p>\n

R\u00e9sum\u00e9<\/strong><\/p>\n

Les cons\u00e9quences neuro-comportementales et physiologiques, suite \u00e0 l\u2019administration sub chronique du tolu\u00e8ne (Tol), ont \u00e9t\u00e9 examin\u00e9es chez le rat Wistar femelle gestante. Un quart de la concentration de la DL50 du Tol a \u00e9t\u00e9 inject\u00e9 en IP chez les rattes gestante, du 4\u00e8me au 14\u00e8me jour de la gestation. Les pr\u00e9l\u00e8vements de sang et la mesure des taux s\u00e9riques de progest\u00e9rone et de LH (hormone lut\u00e9inisante) ont \u00e9t\u00e9 r\u00e9alis\u00e9es au 7\u00e8me jour de gestation (3\u00e8me jour du traitement), au 14\u00e8me jour (dernier jour du traitement) et apr\u00e8s la mise bas (10\u00e8me jour apr\u00e8s l’arr\u00eat du traitement). Apr\u00e8s la mise bas qui co\u00efncide avec le 21\u00e8me jour, nous avons test\u00e9 l\u2019efficacit\u00e9 d\u2019un agoniste GABAergique, le Clonazepam au cours de la nage forc\u00e9e (mod\u00e9lisation animal de la d\u00e9pression). Apr\u00e8s d\u00e9capitation, le cerveau, les surr\u00e9nales et les ovaires ont \u00e9t\u00e9 pes\u00e9s et nous avons calcul\u00e9 les poids relatifs de ces organes. Nos r\u00e9sultats montrent que l’application d’un stress chronique sous tolu\u00e8ne a entra\u00een\u00e9 des perturbations du syst\u00e8me endocrinien (taux plasmatiques de LH et de progest\u00e9rone) et pond\u00e9rale (poids relatif du cerveau, ovaires et surr\u00e9nales) qui semblent \u00eatre irr\u00e9versibles chez les rattes non gestantes trait\u00e9es au Tol. Par contre, le m\u00eame traitement associ\u00e9 \u00e0 la gestation r\u00e9v\u00e8le un effet de r\u00e9tablissement dix jours apr\u00e8s l’arr\u00eat du traitement. L’inefficacit\u00e9 du traitement au Clonaz\u00e9pam enregistr\u00e9e chez les animaux Tol s’av\u00e8re efficace chez le lot TolG. La gestation semble jouer un effet mod\u00e9rateur sur la nocivit\u00e9 et la neurotoxicit\u00e9 du tolu\u00e8ne, probablement par des neurost\u00e9ro\u00efdes.
\nMots cl\u00e9s:<\/strong> Gestation, Tolu\u00e8ne, Progest\u00e9rone, LH, Neurost\u00e9roides, Nage forc\u00e9e<\/p>\n","protected":false},"excerpt":{"rendered":"

Num\u00e9ro de la revue: 25 Auteurs: Asma Latreche, Hac\u00e8ne Frih, Bachir Ali Rachedi, Redha Djenidi, Kamilia Guedri, Hakima Taya, Leila Sahraoui & Abdelkrim Tahraoui Laboratoire de Neuroendocrinologie Appliqu\u00e9e, D\u00e9partement de Biologie, Facult\u00e9 des sciences, Universit\u00e9 Badji Mokhtar Annaba, BP 12 … Lire la suite »<\/span><\/a><\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[686],"tags":[728,731,733,732,730,729],"class_list":["post-3882","post","type-post","status-publish","format-standard","hentry","category-synthese-n-25","tag-gestation","tag-lh","tag-nage-forcee","tag-neurosteroides","tag-progesterone","tag-toluene"],"_links":{"self":[{"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/posts\/3882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3882"}],"version-history":[{"count":2,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/posts\/3882\/revisions"}],"predecessor-version":[{"id":3885,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=\/wp\/v2\/posts\/3882\/revisions\/3885"}],"wp:attachment":[{"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/synthese.univ-annaba.dz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}